Objective To explore and analyze the analgesic effect of ultrasound-guided transversus abdominis plane(TAP)block in patients with acute pancreatitis(AP).Methods A total of 110 AP patients admitted to the Department of Critical Care Medicine of Affiliated Hospital of Gansu Medical College from March 2019 to June 2022 were randomly divided into the observation group(using ultrasound-guided TAP block for analgesia)and the control group(using routine analgesia),with 55 patients in each group.The visual analogue scale(VAS)score of patients at T1(1 h),T2(6 h),T3(12 h)and T4(24 h)after extubation was compared between the two groups,the changes of serum inflammatory factors(C-reactive protein[CRP],tumor necrosis factor-alpha[TNF-α]and interleukin-6[IL-6])and stress response indicators(epinephrine[E]and norepinephrine[NE])were compared before induction and 5 minutes after extubation,and the complications were recorded.Results The VAS score of the observation group at T1,T2,T3 and T4 after extubation was lower than that of the control group,with statistically significant difference(P＜0.05).The time to getting out of bed and length of stay in the observation group were shorter than those in the control group,with statistically significant differences(P＜0.05).The levels of inflammatory factors and stress response in the observation group were lower than those in the control group 5 minutes after extubation,with statistically significant differences(P＜0.05).There was no significant difference in the total incidence of complications between the two groups(P＞0.05).Conclusion Ultrasound-guided TAP block has a significant analgesic effect on AP patients,which can effectively reduce inflammatory response and stress response,and is worth popularizing.
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