Study on the early diagnostic value of thromboelastography combined with prethrombotic molecular markers in disseminated intravascular coagulation
Objective To explore the early diagnostic value of thromboelastography(TEG)combined with prethrombotic molecular markers in disseminated intravascular coagulation(DIC).Methods A retrospective analysis was conducted on 100 suspected DIC patients admitted to the Intensive Care Unit of Yiyang Central Hospital from December 2022 to December 2023.According to the Chinese disseminated intravascular coagulation scoring system(CDSS),they were divided into non-dominant DIC group and dominant DIC group.The TEG parameters such as coagulation reaction time(R value),final strength(MA value),coagulation formation time(K value)and coagulation formation rate(α angle),and the levels of prethrombotic molecular markers such as thrombomodulin(TM),α2-plamininhibitor-plasmincomplex(PIC)and thrombin-antithrombin complex(TAT),were compared between the two groups.Pearson linear correlation was used to analyze the correlation between prethrombotic molecular markers and TEG parameters.The diagnostic efficacy of prethrombotic molecular markers,TEG parameters and their combined detection were evaluated by using receiver operating characteristic(ROC)curve.Results The R and K values of patients in the dominant DIC group were higher than those in non-dominant DIC group,and the levels of TAT,TM,and PIC were higher than those in the non-dominant DIC group,while the α angle and MA value were lower than those in non-dominant DIC group,with statistically significant difference(P＜0.05).In the dominant DIC group,K value and R value were positively correlated with TAT,TM and PIC,while MA value and α angle were negatively correlated with TAT,TM and PIC(P＜0.05).The area under the curve was 0.818 and 0.841 for the combined detection of TEG parameters and prethrombotic molecular markers,respectively,and increased to 0.914 for the combined detection of TEG parameters and prethrombotic molecular markers,with a sensitivity of 90.5％and a specificity of 98.86％.Conclusion There is a correlation between prethrombotic molecular markers and TEG parameters,and the combination of TEG parameters and molecular markers has more evaluative value than separate detection in the diagnosis of early disseminated intravascular coagulation,making it suitable for widespread clinical promotion.
Disseminated intravascular coagulationPrethrombotic molecular markersThromboelastographyEvaluative value
万方数据
维普
