With the discovery of the second receptor CXC chemokine receptor 7(CXCR7)of chemokine CXC motif ligand 12(CXCL12),the signal transduction of CXC12 is improved,which is different from CXCL12-CXCR4 in activation mode to maintain homeostasis and regulate the occurrence and development of various diseases.It also enriches the binding mechanism of CXCL12 and its chemokine receptor 4(CXCR4).They compete with each other and cooperate with each other,and have different signal transduction modes in different organism environments.In this paper,the biological structures,functions and biological effects of signal transduction of CXCL12,CXCR4 and CXCR7 in recent years are reviewed,in order to have a more comprehensive understanding of the above factors and provide basic theoretical reference for further in-depth research.
维普
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