Combined analysis of network pharmacology and molecular docking on the anti-lung cancer mechanism of Cordyceps cicadae Shing
Objective To explore the anti-lung cancer mechanism of Cordyceps cicadae Shing.Methods By searching databases such as TCMSP,Symmap,SwissTargetPrediction,GeneCards,PubChem,and using software such as Cytoscape 3.7.2,AutoDock and Pymol,network pharmacology analysis and molecular docking analysis were carried out.Results Four important components and 326 potential targets were screened.Signal pathways with higher number of Kyoto encyclopedia of genes and genomes enrichment targets include cancer pathway,chemical carcinogenesis-receptor activation,neuroactive ligand-receptor interaction and inflammatory mediator regulation of transient receptor potential channel.Molecular docking verified that four important components and four key targets could spontaneously bind.Conclusion After the Cordyceps cicadae Shing acts on the body,it intervenes in lung cancer through key targets such as peroxisome proliferative activated receptor,prostaglandin-endoperoxide synthase 2,recombinant amyloid precursor protein and protein kinase cAMP-activated catalytic subunit alpha.
万方数据
维普
