首页|二至丸合丹参饮治疗阴虚血瘀型慢性胃炎合并老年睡眠障碍的临床研究

二至丸合丹参饮治疗阴虚血瘀型慢性胃炎合并老年睡眠障碍的临床研究

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目的 观察二至丸合丹参饮治疗阴虚血瘀型慢性胃炎合并老年睡眠障碍的临床疗效。方法 选取2022年6 月至 2024 年 1 月于淄博市中医医院诊断为慢性胃炎合并老年睡眠障碍属"阴虚血瘀"型的患者 90 例,按照随机数表法分为对照组和观察组,每组各 45 例,对照组用"四联疗法"联合阿普唑仑治疗,观察组在对照组基础上加用二至丸合丹参饮汤药治疗,两组患者均治疗 4 周,观察两组患者治疗前后胃镜结果,幽门螺杆菌转阴率,匹兹堡睡眠质量指数量表(PSQI),失眠严重程度指数量表(ISI),中医证候评分的指标,并比较总有效率。结果 治疗后,观察组总有效率为 64。44%,高于对照组的 31。11%,差异有统计学意义(P<0。05);治疗后两组患者胃镜结果,幽门螺杆菌阳性率、PSQI睡眠量表评分、ISI失眠严重程度量表评分、中医证候评分部分项目均较治疗前改善,差异有统计学意义(P<0。05),且观察组在各比较项目改善情况均优于同期对照组,差异有统计学意义(P<0。05)。结论 二至丸合丹参饮治疗阴虚血瘀型慢性胃炎合并老年睡眠障碍疗效确切,改善患者慢性胃炎情况,提高老年睡眠障碍患者睡眠质量,值得进一步研究和应用。
Clinical study on Erzhi Pill combined with Danshen Decoction in treating chronic gastritis with Yin deficiency and blood stasis complicated with senile sleep disorder
Objective To observe the clinical effect of Erzhi Pill combined with Danshen Decoction on chronic gastritis with Yin deficiency and blood stasis complicated with senile sleep disorder.Methods From June 2022 to 2024,a total of 90 patients with chronic gastritis complicated with senile sleep disorder were selected and divided into control group and observation group according to the random number table method,with 45 cases in each group.The control group was treated with"quadruple therapy"combined with alprazolam,while the observation group was treated with Erzhi Pill and Danshen Decoction on the basis of the control group.The two groups were treated for 4 weeks,and the gastroscopy results,negative rate of Helicobacter pylori,Pittsburgh Sleep Quality Index(PSQI),The Insomnia Severity Index(ISI)and TCM syndrome score of the two groups were observed before and after treatment,and the total effective rate was compared.Results After treatment,the effective rate of the observation group was 64.44%higher than that of the control group(31.11%),with statistically significant difference(P<0.05).After treatment,the gastroscopy results of the two groups showed that the positive rate of Helicobacter pylori,PSQI scale,ISI scale and TCM syndrome score were all better than those before treatment,with statistically significant difference(P<0.05),and the improvement of the observation group was better than that of the control group at the same period,with statistically significant difference(P<0.05).Conclusion Erzhi Pill combined with Danshen Decoction is effective in the treatment of chronic gastritis with senile sleep disorder,which can improve the chronic gastritis and improve the sleep quality of senile sleep disorder patients,and is worthy of further study and application.

Erzhi PillDanshen DecoctionYin deficiency and blood stasisChronic gastritisSenile sleep disorder

胡淑琴、郭斯一、张雯慧

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山东省淄博市中医医院脾胃病科,山东淄博 255300

山东中医药大学第一临床医学院,山东济南 255014

黑龙江中医药大学第一临床医学院,黑龙江哈尔滨 150006

二至丸 丹参饮 阴虚血瘀 慢性胃炎 老年睡眠障碍

2024

中国医药科学
海峡两岸医药卫生交流协会 二十一世纪联合创新(北京)医药科学研究院

中国医药科学

影响因子:1.083
ISSN:2095-0616
年,卷(期):2024.14(17)