Clinical observation of Wumei Pills in the treatment of multidrug-resistant patients with cold-heat mixed colorectal cancer
Objective To observe the efficacy and safety of Wumei Pills in the treatment of multidrug-resistant patients with cold-heat mixed colorectal cancer.Methods A total of 60 patients with multidrug resistance of colorectal cancer admitted to the Department of Oncology of the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine from January 2021 to June 2023 were selected and randomly divided into the observation group(n=30)and the control group(n=30).The control group were treated with targeted therapy of regorafenib,and the observation group were treated with Wumei Pills on the basis of the treatment of the control group.21 days was considered as a cycle,with a total of 2 cycles of treatment.The objective therapeutic efficacy,TCM syndrome score,tumor markers,quality of life and adverse reactions(ADRs)of the two groups of patients were observed respectively.Results After treatment,the objective effective rate and disease control rate of the observation group were higher than those of the control group,with statistically significant differences(P<0.05).After treatment,the TCM syndrome score of the observation group was lower than that of the control group,with statistically significant difference(P<0.05).After treatment,the levels of carcinoembryonic antigen(CEA)and carbohydrate antigen 199(CA199)in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).After treatment,the quality of life in the observation group was better than that in the control group,with statistically significant difference(P<0.05).There was no statistically significant difference in the incidence of ADRs between the two groups(P>0.05).Conclusion Wumei Pills can inhibit the progress of patients with multi-drug resistance of cold-heat mixed colorectal cancer,alleviate clinical symptoms and improve the QoL of patients.
Wumei PillsColorectal cancerMulti-drug resistanceCold-heat mixed syndrome type
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