Meta-analysis of clinical efficacy and safety of Xiangsha Liujunzi Decoction combined with chemotherapy in the treatment of advanced gastric cancer
Objective To systematically evaluate the safety and efficacy of Xiangsha Liujunzi Decoction combined with chemotherapy in the treatment of advanced gastric cancer,so as to analyze the evidence level through GRADE quality evaluation.Methods The literatures published in China National Knowledge Internet,Wanfang Data Knowledge Service Platform,China Science and Technology Journal Database,PubMed,Cochrane Library and Web of Science database from establishment to July 2023 were searched,and literature screening and elimination and Meta-analysis were conducted by using EndNote X9 and Review Manager 5.3.Results A total of 18 literatures containing 1430 research cases were included,and they were divided into the study group(n=717)and the control group(n=713).The Meta-analysis results showed that the combination of Xiangsha Liujunzi Decoction and chemotherapy could improve the tumor's overall response rate(OR=2.17,95%CI:1.65-2.85,P<0.000 01)and the TCM symptom score(OR=4.89,95%CI:2.40-9.98,P<0.0001),and the quality of life(MD=6.40,95%CI:4.19-8.60,P<0.000 01).The incidences of malignant vomiting(OR=0.14,95%CI:0.08-0.24,P<0.0001)and leukopenia(OR=0.35,95%CI:0.17-0.72,P=0.005)were reduced,mainly in the incidence of gradeⅢ-Ⅳ leukopenia(OR=0.22,95%CI:0.12-0.38,P<0.000 01).However,there was statistical significance in the Meta-analysis of abdominal diarrhea(OR=0.31,95%CI:0.09-0.32,P<0.000 01),but without remarkable difference.Conclusion Xiangsha Liujunzi Decoction combined with chemotherapy can improve the therapeutic efficacy of advanced gastric cancer and reduce the occurrence of adverse reactions,which provides a theoretical basis for clinical treatment of gastric cancer.
万方数据
维普
