Study on the diagnostic value of neutrophil ratio in ascites combined with serum inflammatory factors in cirrhosis ascites complicated with spontaneous bacterial peritonitis
Objective To explore the diagnostic value of serum interleukin-6(IL-6),procalcitonin(PCT),hypersensitive C-reactive protein(hs-CRP)combined with ascitic neutrophil ratio(N%)in the diagnosis of spontaneous bacterial peritonitis(SBP)in patients with cirrhosis ascites.Methods Clinical data of 66 patients with liver cirrhosis and ascites admitted to the Second Affiliated Hospital of Kunming Medical University from May 2020 to August 2023 were selected.The patients were divided into an experimental group(36 cases)and a control group(30 cases)based on whether they were complicated with SBP or not.Serum IL-6,PCT,hs-CRP,and ascites N%were measured,and the results of the two groups were compared.Receiver operating characteristic(ROC)curve was created to evaluate the diagnostic value of serum IL-6,PCT,hs-CRP,and ascites N%for liver cirrhosis and ascites complicated with SBP.The diagnostic efficacy of single and combined tests of the four indicators was compared.Results The levels of serum IL-6,PCT,hs-CRP and ascites N%in the experimental group were significantly higher than those in the control group,and the difference was statistically significant(P<0.05).ROC analysis showed that the AUC of serum IL-6,PCT,hs-CRP and ascites was 0.779,0.854,0.808 and 0.892,respectively.The Cut-Off values were 47.68,0.22,9.47 and 22.10 respectively;the sensitivity(88.90%vs.61.10%,80.60%,91.70%,83.30%)and specificity(100.00%vs.90.00%,76.60%,60.00%)of the four combined tests were significantly higher than those of single tests for serum IL-6,PCT,hs-CRP,and ascites N%,except for hs-CRP.Conclusion The levels of serum IL-6,PCT,hs-CRP and ascites N%in patients with cirrhosis ascites complicated with SBP increased significantly.The combined detection of the four indicators has certain diagnostic value for cirrhosis ascites complicated with SBP,which is beneficial to early diagnosis and intervention of SBP.
CirrhosisSpontaneous bacterial peritonitisNeutrophil ratioInterleukin-6ProcalcitoninHypersensitive C-reactive protein
万方数据
维普
