结核菌培养联合结核分枝杆菌-DNA检测对菌阴肺结核诊断效能的研究

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中文摘要：目的探究结核菌培养联合结核分枝杆菌-DNA检测对菌阴肺结核的诊断效能。方法选取 2021 年9 月至 2022 年 9 月阳江市公共卫生医院收治的 188 例疑似菌阴肺结核患者，均进行结核菌培养、结核分枝杆菌-DNA检测。以组织培养及病理检查为"金标准"。比较结核菌培养、结核分枝杆菌-DNA检测单独检测、联合检测菌阴肺结核的诊断结果以及诊断效能。结果 188 例疑似菌阴肺结核患者中 132 例确诊为阳性，结核菌培养检测检出阳性 115 例，阴性 73 例;结核分枝杆菌-DNA检测检出阳性 107 例，阴性 81 例;联合检测检出阳性 134 例，阴性 54 例。结核菌培养联合结核分枝杆菌-DNA检测对菌阴肺结核的灵敏度、阴性预测值、准确率(91。67%、79。63%、87。23%)高于结核菌培养检测(78。79%、61。64%、79。26%)、结核分枝杆菌-DNA检测(75。00%、59。26%、78。19%)，差异有统计学意义(P<0。05)。结核菌培养联合结核分枝杆菌-DNA检测对菌阴肺结核的特异度、阳性预测值(76。79%、90。30%)与结核菌培养检测(80。36%、90。43%)、结核分枝杆菌-DNA检测(85。71%、92。52%)比较，差异无统计学意义(P>0。05)。结论结核菌培养联合结核分枝杆菌-DNA检测对菌阴肺结核进行诊断，有利于提升诊断灵敏度、阴性预测值、准确率，诊断效能较高。

外文标题：Study on the diagnostic efficacy of tubercle bacillus culture combined with mycobacterium tuberculosis-DNA detection in bacterial negative pulmonary tuberculosis

外文摘要：Objective To explore the diagnostic efficacy of tubercle bacillus culture combined with mycobacterium tuberculosis-DNA detection in bacterial negative pulmonary tuberculosis.Methods A total of 188 patients with suspected bacterial negative pulmonary tuberculosis admitted to Yangjiang Public Health Hospital from September 2021 to September 2022 were selected for tubercle bacillus culture and mycobacterium tuberculosis-DNA detection.Tissue culture and pathology as the"gold standard".The diagnostic results and efficacy of tubercle bacillus culture,mycobacterium tuberculosis-DNA detection alone,and combined detection of bacterial negative pulmonary tuberculosis were compared.Results Out of 188 patients with suspected bacterial negative pulmonary tuberculosis,132 were confirmed positive,and tubercle bacillus culture test detected 115 positive and 73 negative cases.107 cases were positive and 81 cases were negative in the mycobacterium tuberculosis DNA-detection.Combined testing detected 134 positive cases and 54 negative cases.The sensitivity,negative predictive value,and accuracy(91.67%,79.63%,87.23%)of tubercle bacillus culture combined with mycobacterium tuberculosis DNA-detection for bacterial negative pulmonary tuberculosis were higher than those of tubercle bacillus culture test(78.79%,61.64%,79.26%)and mycobacterium tuberculosis DNA-detection(75.00%,59.26%,78.19%),with statistical significance(P<0.05).The specificity and positive predictive value(76.79%,90.30%)of tubercle bacillus culture combined with mycobacterium tuberculosis DNA-detection for bacterial negative pulmonary tuberculosis were compared with those of tubercle bacillus culture test(80.36%,90.43%)and mycobacterium tuberculosis DNA-detection(85.71%,92.52%),and there was no statistically significant difference(P>0.05).Conclusion The combination of tubercle bacillus culture and mycobacterium tuberculosis DNA-detection for the diagnosis of bacterial negative pulmonary tuberculosis is beneficial for improving diagnostic sensitivity,negative predictive value,accuracy,and high diagnostic efficiency.

外文关键词：

Tubercle bacillus cultureMycobacterium tuberculosis DNA-detectionBacterial negative pulmonary tuberculosisDiagnostic efficiency

作者：

陈菊、陈建仁、吴修宇

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作者单位：

广东省阳江市公共卫生医院检验科,广东阳江 529500

关键词：

结核菌培养结核分枝杆菌-DNA检测菌阴肺结核诊断效能

出版年：

2024

DOI：