Study on the correlation between cellular immunity and inflammatory markers in patients with acute exacerbation of bronchiectasis
Objective To analyze the correlation between CD3+,CD4+,and CD8+T lymphocytes and inflammatory markers such as neutrophil to lymphocyte ratio(NLR),platelet to lymphocyte ratio(PLR),and C-reactive protein(CRP)by detecting them.Methods A total of 50 patients with acute exacerbation of bronchiectasis admitted to the Department of Respiratory and Critical Care Medicine of Hongqi Hospital Affiliated to Mudanjiang Medical University from October 2022 to April 2023 were enrolled in the bronchiectasis group,and 50 healthy individuals who underwent physical examinations during the same period were selected as the control group.All patients were required to complete T lymphocyte subgroups,blood routine,CRP and other relevant examinations.Both groups of patients underwent CD3+,CD4+,and CD8+T lymphocyte testing,and the levels of T lymphocytes,NLR,PLR,CRP and other inflammatory indicators were compared between the two groups of patients;At the same time,the correlation between cellular immune indicators and inflammatory indicators was analyzed.Results The levels of CD3+,CD4+,and CD8+T lymphocytes in the bronchiectasis group were lower than those in the control group(P<0.05).The levels of PLR,NLR,and CRP in the bronchiectasis group were higher than those in the control group(P<0.05).In patients with bronchiectasis,PLR,NLR were negatively correlated with CD3+T lymphocytes(P<0.05).CRP was negatively correlated with CD4+T lymphocytes(P<0.05).Conclusion Patients with acute exacerbation of bronchiectasis have decreased levels of CD3+,CD4+,and CD8+T lymphocytes,suggesting that CD4+and CD8+T lymphocytes may play a certain role in the acute exacerbation of bronchiectasis.The higher the NLR,PLR,and CRP in patients with acute exacerbation of bronchiectasis,the more severe the inflammatory response,and the lower the level of T lymphocytes in the body.
BronchiectasisCellular immunityNeutrophil to lymphocyte ratioPlatelet to lymphocyte ratioC-reactive protein
万方数据
维普
