摘要
目的 通过检测CD3+、CD4+、CD8+T淋巴细胞,同时与中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR)、C反应蛋白(CRP)炎症指标做相关性分析.方法 选取 2022 年 10 月至 2023 年 4 月牡丹江医学院附属红旗医院呼吸与危重症医学科收治的支气管扩张急性加重期患者 50 例纳入支扩组,选取同期健康体检人员 50 例纳入对照组,所有患者均需完成T淋巴细胞亚群、血常规、CRP等相关检查.两组患者均进行CD3+、CD4+、CD8+T淋巴细胞检测,比较两组患者的T淋巴细胞以及NLR、PLR、CRP等炎症指标的水平;同时将细胞免疫指标与炎症指标做相关性分析.结果 CD3+、CD4+、CD8+T淋巴细胞在支扩组的水平低于对照组(P<0.05).PLR、NLR、CRP在支扩组中的水平高于对照组(P<0.05).在支扩组患者中,PLR、NLR与CD3+T淋巴细胞呈负相关(P<0.05);CRP与CD4+T淋巴细胞呈负相关(P<0.05).结论 支气管扩张急性加重期患者CD3+、CD4+、CD8+T淋巴细胞降低,推测CD4+、CD8+T淋巴细胞在支气管扩张急性加重期中发挥一定作用.支气管扩张急性加重期患者的NLR、PLR、CRP越高,炎症反应越重,机体的T淋巴细胞水平越低.
Abstract
Objective To analyze the correlation between CD3+,CD4+,and CD8+T lymphocytes and inflammatory markers such as neutrophil to lymphocyte ratio(NLR),platelet to lymphocyte ratio(PLR),and C-reactive protein(CRP)by detecting them.Methods A total of 50 patients with acute exacerbation of bronchiectasis admitted to the Department of Respiratory and Critical Care Medicine of Hongqi Hospital Affiliated to Mudanjiang Medical University from October 2022 to April 2023 were enrolled in the bronchiectasis group,and 50 healthy individuals who underwent physical examinations during the same period were selected as the control group.All patients were required to complete T lymphocyte subgroups,blood routine,CRP and other relevant examinations.Both groups of patients underwent CD3+,CD4+,and CD8+T lymphocyte testing,and the levels of T lymphocytes,NLR,PLR,CRP and other inflammatory indicators were compared between the two groups of patients;At the same time,the correlation between cellular immune indicators and inflammatory indicators was analyzed.Results The levels of CD3+,CD4+,and CD8+T lymphocytes in the bronchiectasis group were lower than those in the control group(P<0.05).The levels of PLR,NLR,and CRP in the bronchiectasis group were higher than those in the control group(P<0.05).In patients with bronchiectasis,PLR,NLR were negatively correlated with CD3+T lymphocytes(P<0.05).CRP was negatively correlated with CD4+T lymphocytes(P<0.05).Conclusion Patients with acute exacerbation of bronchiectasis have decreased levels of CD3+,CD4+,and CD8+T lymphocytes,suggesting that CD4+and CD8+T lymphocytes may play a certain role in the acute exacerbation of bronchiectasis.The higher the NLR,PLR,and CRP in patients with acute exacerbation of bronchiectasis,the more severe the inflammatory response,and the lower the level of T lymphocytes in the body.
维普
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