Research progress on protective mechanism of sodium valproate after stroke
Stroke is a common neurological disorder that leads to significant neurological damage and disability.Although there are currently multiple treatment options available,there is still a lack of effective drugs that have a protective effect after stroke.In recent years,sodium valproate,as a broad-spectrum antiepileptic drug,has attracted attention for its potential neuroprotective effects.Research has shown that sodium valproate can alleviate the inflammatory reaction after stroke by inhibiting the expression of inflammatory mediators,inhibiting histone deacetylase,and inhibiting the activation of microglia and astrocytes;it can regulate related genes and enhance the content of inhibitory neurotransmittersγ-aminobutyric acid in the brain,inhibit cell apoptosis,regulate signaling pathways related to cell apoptosis,such as mitogen-activated protein kinase/extracellular regulated protein kinase(MAPK/ERK)signaling pathway,and c-Jun N-terminal kinase(JNK)signaling pathway,which can inhibit cell apoptosis;and it can induce the expression of heat shock proteins(HSPs),such as HSP70,which can protect the nervous tissue after stroke.This paper will review the research progress on the protective mechanism of sodium valproate after stroke in recent years.
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维普
