Effect of total glucosides of paeonia on serum B cell activating factor in children with juvenile rheumatoid arthritis
Objective To explore the clinical efficacy of total glucosides of paeonia on children with juvenile rheumatoid arthritis and its impact on serum B cell activating factors.Methods A total of 40 children with rheumatoid arthritis admitted to the Department of Paediatrics,Zhongshan Hospital of Traditional Chinese Medicine from August 2019 to August 2021 were selected as the study subjects.They were randomly divided into a control group(20 cases)and a treatment group(20 cases)using a random number table method.The control group only received oral ibuprofen sustained-release suspension,while the treatment group received both oral ibuprofen sustained-release suspension and total glucosides of paeonia capsules for treatment.Both groups received continuous treatment for 12 weeks.The disappearance time of joint fever,swelling,morning stiffness and other symptoms,the changes of erythrocyte sedimentation rate,rheumatoid factors,B cell activating factor and C-reactive protein were observed in the two groups after treatment.Results After treatment,the total effective rate of the treatment group was higher than that of the control group,and the disappearance time of joint fever,swelling,and morning stiffness symptoms in the treatment group was shorter than that of the control group.In addition,the erythrocyte sedimentation rate,rheumatoid factors,C-reactive protein levels,and B cell activating factor were all lower than those of the control group,and the difference was statistically significant(P＜0.05).There was no statistically significant difference i n the overall incidence ofadverse reactions between the two groups of children(P＞0.05).Conclusion The total glucosides of paeonia are used to treat children with juvenile rheumatoid arthritis,and their clinical efficacy is significant.They can inhibit the expression of B cell activating factors,reduce the levels of erythrocyte sedimentation rate and C-reactive protein in children,improve the clinical symptoms of rheumatoid arthritis in children,and have a good safety factor.They are worthy of clinical promotion and use.
Total glucosides of paeoniaRheumatoid arthritisChildren patientClinical efficacy
万方数据
维普
