Clinical application value of immunohistochemical T lymphocyte subsets analysis in unstable angina
Objective To explore the influence of immunohistochemical T lymphocyte subsets analysis on the recurrence risk of unstable angina(UA).Methods From January 2022 to February 2023,96 patients with UA and 75 patients without coronary heart disease(as the control group)who were hospitalized in the Department of Cardiology,Yancheng Traditional Chinese Medicine Hospital were included in this retrospective study.Gender,age,history of diabetes,history of hypertension,white blood cell count,lymphocyte count,neutrophil count,fasting blood glucose,low-density lipoprotein cholesterol,high-density lipoprotein cholesterol,total cholesterol,triglyceride and immunohistochemical T lymphocyte subsets(CD3+,CD4+,CD8+,CD4+/CD8+)were compared between the two groups.Simultaneously,a binomial logistic regression analysis was conducted to identify independent risk factors for the onset of UA.Finally,the ROC curve analysis was used to determine the optimal cutoff value for predicting UA incidence using the CD4+/CD8+ratio.Results There was a statistically significant difference(P＜0.05)in age,presence of hypertension,fasting blood glucose,high-density lipoprotein,and low-density lipoprotein between the UA group and the control group.Compared with the control group,the lymphocyte subsets(CD4+,CD8+,CD3+,CD4+/CD8+)of patients with UA showed statistically significant differences(P＜0.05).Logistic regression analysis showed that age,CD4+/CD8+ratio,and UA were independently correlated(P＜0.05).The diagnostic value of CD4+/CD8+in predicting plaque instability in patients with UA was analyzed by ROC curve analysis,and the optimal cutoff value was found to be 2.915.Conclusion The changes in T cell subsets in peripheral blood can weaken the stability of plaques,leading to and catalyzing the occurrence and development of UA.In patients with UA,the CD4+/CD8+ratio may be an independent predictive factor for evaluation.
万方数据
维普
