Analysis of EMT process and Tspan-5 expression in gastric adenocarcinoma tumors in high incidence areas of gastric cance
Objective To explore the relationship between the epithelial-mesenchymal transition(EMT)process of gastric adenocarcinoma tumor cells in high incidence areas of gastric cancer and the expression of Tspan-5.Methods A total of 108 patients with gastric adenocarcinoma who underwent radical surgery at the First Hospital of Putian City from May 2018 to December 2019 were selected as the study subjects.Immunohistochemical staining was used to detect the positive expression of Tspan-5,E-cadherin,and N-cadherin in tumor tissues.Results The positive expression of Tspan-5 was 48.1％(52 cases),that of E-cadherin was 25.0％(27 cases)and that of N-cadherin was 56.5％(61 cases).The positive expression of Tspan-5,E-cadherin and N-cadherin was not related to gender and age(P＞0.05),but was related to tumor status(stage)(P＜0.05).As the tumor progressed,the positive rates of Tspan-5 and N-cadherin increased,while the positive rates of E-cadherin decreased.The correlation analysis showed that the positive rate of Tspan-5 was positively correlated with E-cadherin and negatively correlated with N-cadherin(P＜0.05),and the positive rate of E-cadherin was negatively correlated with N-cadherin(P＜0.05).Conclusion The high expression of Tspan-5 in gastric adenocarcinoma is closely related to the tumor EMT process,and Tspan-5 may become an important target for early clinical diagnosis,intervention,and prognosis evaluation.
万方数据
维普
