摘要
目的 探讨司美格鲁肽对2型糖尿病(T2DM)合并高脂血症患者糖脂代谢的影响.方法 选取2022年1月至2023年12月在江苏大学附属武进医院内分泌科住院及门诊收治的T2DM合并高脂血症患者共166例,男79例,女87例,予司美格鲁肽皮下注射治疗,比较用药前、后的腰围(WC)、体重指数(BMI)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FBG)、早餐后2小时血糖(2hPBG)、糖化血红蛋白(HbA1c)的变化.结果 司美格鲁肽治疗1个月后,FBG、2hPBG、TC、TG、LDL-C、HDL-C、BMI较治疗前降低,差异均有统计学意义(P＜0.05);治疗3个月后FBG、2 h PBG、HbA1c、TC、TG、LDL-C、WC、BMI 较治疗前降低,其中 FBG、2 h PBG、TC、TG、LDL-C、WC、BMI 较治疗 1 个月后进一步下降,差异均有统计学意义(P＜0.05).结论 司美格鲁肽治疗T2DM伴高脂血症,可有效改善患者血糖、体格指标及血脂谱.
Abstract
Objective To investigate the effect of semaglutide on glucose and lipid metabolism in patients with type 2 diabetes mellitus(T2DM)complicated with hyperlipidemia.Methods A total of 166 T2DM patients with hyperlipidemia,including 79 males and 87 females,who were hospitalized and outpatient in the Department of Endocrinology,Wujin Hospital Affiliated with Jiangsu University from January 2022 to December 2023,were selected and treated with subcutaneous injection of semaglutide.The changes of waist circumference(WC),body mass index(BMI),total cholesterol(TC),triglycerides(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),fasting blood glucose(FBG),2-hour postprandial blood glucose(2 h PBG),and hemoglobin A1c(HbA1c)were compared before and after medication.Results After one month's treatment,FBG,2 h PBG,TC,TG,LDL-C,HDL-C and BMI were significantly lower than those before treatment(P＜0.05).After three months of treatment,FBG,2 h PBG,HbA1c,TC,TG,LDL-C,WC and BMI decreased compared with those before treatment,among which FBG,2 h PBG,TC,TG,LDL-C,WC and BMI further decreased compared with those after one month of treatment,and the differences were statistically significant(P＜0.05).Conclusion Semaglutide can effectively improve blood glucose,physical indicators,and lipid profile in patients with T2DM complicated with hyperlipidemia.
维普
万方数据