目的 探讨血管紧张素原(AGT)-M235T、内皮型一氧化氮合酶(eNOS)-T786C基因多态性与急性心肌梗死(AMI)的相关性。方法 选取2021年7月至2023年7月在玉林市中医医院就诊的AMI患者200例作为AMI组，同期体检健康者200名作为对照组，比较两组的基因型及等位基因频数的差异。结果 AMI组男女间的eNOS-T786C基因型及等位基因频数比较，差异有统计学意义(P＜0。05);对照组男女间的AGT-M235T基因型、AGT-M235T等位基因及eNOS-T786C基因型频数比较，差异有统计学意义(P＜0。05)。两组女性的eNOS-T786C基因型及等位基因频数比较，差异有统计学意义(P＜0。05)。分别以GG和TT基因型作为参照进行二元logistic回归分析，结果表明AA及CC基因型可能是AMI患病的危险因素(AA:OR=2。281，P＜0。05;CC:OR=2。934，P＜0。05)，而 GA 基因型可能是 AMI 患病的保护因素(OR=0。803，P＜0。05)。结论 AGT-M235T的AA基因型及eNOS-T786C的CC基因型与AMI易感性密切相关，临床需要重视AMI患者相关基因型的危险因素及保护因素。
Correlation between AGT-M235T and eNOS-T786C gene polymorphisms and acute myocardial infarction
Objective To explore the correlation between the Angiotensinogen(AGT)-M235T and endothelial nitric oxide synthase(eNOS)-T786C gene polymorphisms with acute myocardial infarction(AMI).Methods A study was conducted comparing the genotype and allele frequencies between 200 patients diagnosed with acute myocardial infarction(AMI)who sought treatment at the Traditional Chinese Medicine Hospital of Yulin between July 2021 and July 2023,and 200 healthy individuals who received physical examinations during the same timeframe.Results The frequency of eNOS-T786C genotypes and alleles between males and females in the AMI group showed statistically significant differences(P＜0.05).The frequency of AGT-M235T genotype,AGT-M235T allele,and eNOS-T786C genotype between males and females in the control group showed statistically significant differences(P＜0.05).The frequency of eNOS-T786C genotypes and alleles in two groups of women showed a statistically significant difference(P＜0.05).Binary logistic regression analysis,using GG and TT genotypes as reference,compared the AMI group with the control group,AA and CC genotypes may be risk factors for AMI(AA:OR=2.281,P＜0.05;CC:OR=2.934,P＜0.05),while GA genotype may be a protective factor for AMI(OR=0.803,P＜0.05).Conclusion AA genotype of AGT-M235T and CC genotype of eNOS-T786C are closely related to the susceptibility to AMI,so it is necessary to pay attention to the risk factors and protective factors of related genotypes in patients with AMI.
万方数据
维普
