Objective To explore the effect of berberine hydrochloride on the proliferation,migration and invasion of human colon cancer cell SW480 and its possible mechanism.Methods The human colon cancer cell SW480 was divided into experimental group,control group and blank group.The effects of berberine hydrochloride with different concentrations on the proliferation of SW480 cells were determined by CCK8 method,and the survival rate of SW480 cells were calculated.The effects of berberine hydrochloride on the clone formation,migration and invasion of SW480 were confirmed by experiments such as plate clone formation,cell scratch and Transwell.Results Berberine hydrochloride could obviously inhibit the proliferation of SW480 cells in a time and concentration dependent manner.Berberine hydrochloride significantly inhibited the formation,migration and invasion of SW480 cells,and the difference was statistically significant(P＜0.05).Conclusion Berberine hydrochloride has an obvious inhibitory effect on the cloning,proliferation,invasion and migration of cell SW480.
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