血脂相关指标与糖尿病视网膜病变的相关研究进展

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中文摘要：糖尿病视网膜病变(DR)是糖尿病特异性的微血管并发症，主要由血管动脉硬化和炎症引起。DR的危险因素相关研究发现，将血糖控制在良好范围内可有效降低糖尿病患者合并DR的患病率，并改善血脂紊乱，减慢DR病情的进展。脂肪细胞可与巨噬细胞共同作用增加促炎细胞因子、肿瘤坏死因子、促凝物质纤维蛋白原的分泌，并减少脂联素等抗炎细胞因子的分泌，进一步导致代谢紊乱以及DR的进展。当糖尿病患者单个血脂指标正常时，仍会出现血管相关并发症，因此血脂相关复合指标的监测引起了广泛关注。本文综述甘油三酯葡萄糖指数、甘油三酯与高密度脂蛋白胆固醇比值、血浆致动脉粥样硬化指数以及低密度脂蛋白与高密度脂蛋白比值和DR的相关研究进展。

外文标题：Research progress on the correlation between lipid-related indexes and diabetic retinopathy

外文摘要：Diabetic retinopathy(DR)is a specific microvascular complication of diabetes mellitus,which is mainly caused by arteriosclerosis and inflammation.In the study of risk factors of DR,it is found that controlling blood glucose in a good range can effectively reduce the prevalence of diabetic patients complicated with DR,and effectively improving dyslipidemia can slow down the progress of DR.Adipocytes can work together with macrophages to increase the secretion of pro-inflammatory cytokines,tumor necrosis factors and fibrinogen,and reduce the secretion of anti-inflammatory cytokines such as adiponectin,which further leads to metabolic disorders and the progress of DR.However,when a single blood lipid index of diabetic patients is normal,there will still be vascular-related complications,so the lipid-related composite index has attracted widespread attention.This article systematically reviews the research progress of triglyceride-glucose index,the triglycerides to high density lipoprotein cholesterol ratio,the atherogenic index of plasma and the low density lipoprotein cholesterol to high density lipoprotein cholesterol ratio and DR.

外文关键词：

Triglyceride-glucose indexTriglycerides to high density lipoprotein cholesterol ratioAtherogenic index of plasmaLow density lipoprotein cholesterol to high density lipoprotein cholesterol ratioDiabetes mellitusDiabetic retinopathy

作者：

张洋洋、谭丽艳、南晓利、柳扬

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作者单位：

佳木斯大学附属第一医院内分泌与代谢科,黑龙江佳木斯 154000

佳木斯大学口腔医学院口腔病理学教研室,黑龙江佳木斯 154000

佳木斯大学附属第一医院肾内科,黑龙江佳木斯 154000

关键词：

甘油三酯葡萄糖指数甘油三酯与高密度脂蛋白胆固醇比值血浆致动脉粥样硬化指数低密度脂蛋白胆固醇与高密度脂蛋白胆固醇比值糖尿病糖尿病视网膜病变

出版年：

2024

DOI：