Exploring the mechanism of Ge Hua intervention in alcoholic hepatitis based on network pharmacology and molecular docking
Objective To explore the mechanism of Ge Hua in the treatment of alcoholic hepatitis(AH).Methods The active components,action targets and AH-related targets of Ge Hua were collected,and the key core targets were obtained,and protein-protein interaction analysis was conducted on the intersection targets,and the function enrichment analysis was carried out,so as to construct a network of Ge Hua components,intersection targets,diseases and pathways,and carry out molecular docking.Results 166 main components and targets of 17 types of Ge Hua were obtained,699 AH-related targets were identified,and 70 intersection targets between Ge Hua and AH were identified.The main active components of Ge Hua were quercetin,kaempferol,puerarin,and mangiferin β-Sitosterol,with serine/threonine-protein kinase 1(AKT1),tumor necrosis factor(TNF),interleukin(IL)-6,tumor protein p53,IL1B as the key core targets.TNF,IL-17,and mitogen-activated protein kinase were the main signaling pathways.Conclusion Ge Hua may activate AKT1 and TNF proteins through active components such as quercetin,and regulate TNF signaling pathways to treat AH.
万方数据
维普
