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传统制剂滑膜灵颗粒的提取工艺研究

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目的 优选滑膜灵颗粒的提取工艺。方法 利用单因素考察法,分别对苍术挥发油成分及滑膜灵颗粒全方的提取工艺进行研究,从提取时间、料液比、提取次数、浸泡时间等因素考察,优选最佳提取工艺。结果 滑膜灵颗粒中苍术挥发油的提取工艺为苍术粉碎度为80目,料液比1∶15,浸泡时间和蒸馏时间均为2 h;全方的提取工艺为提取时间60 min,料液比1∶10,提取次数2次。结论 结合考虑经济效益和操作性,该方法稳定可靠,能为后期开发滑膜灵颗粒提供依据,为其他中药制剂研发提供思路。
Study on the extraction process of traditional preparation of Hua Mo Ling Granules
Objective To optimize the extraction process of Hua Mo Ling Granules.Methods The extraction process of the component of volatile oil from Atractylodes Lancea and the whole formula of Hua Mo Ling granules were investigated using the single factor test method,respectively,from factors of extraction time,material-liquid ratio,number of times of extraction,and soaking time,to optimize the best extraction process.Results The extraction process of the volatile oil from Atractylodes Lancea in Hua Mo Ling Granules consisted of a crushing degree for Atractylodes Lancea of 80 mesh,a material-liquid ratio of 1∶15,soaking time of 2 h,and distillation time of 2 h.The extraction process of the whole formula consisted of extraction time of 60 min,a material-liquid ratio of1∶10,and 2 times of extraction.Conclusion Taking the economic benefits and operability into consideration,this method is stable and reliable.It can provide a basis for the later development of Hua Mo Ling Granules and support ideas for the development of other Chinese medicinal preparations.

Hua Mo Ling GranulesVolatile oilExtraction processTraditional Chinese medicine preparation

林诗瑶、王建荣、王西林、林忠洲、张玉琴

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福州市第二总医院,福建 福州 350007

福建中医药大学,福建 福州 350007

滑膜灵颗粒 挥发油 提取工艺 中药制剂

2024

中国医药科学
海峡两岸医药卫生交流协会 二十一世纪联合创新(北京)医药科学研究院

中国医药科学

影响因子:1.083
ISSN:2095-0616
年,卷(期):2024.14(19)