首页|DCSTAMP在甲状腺癌中的表达及临床价值

DCSTAMP在甲状腺癌中的表达及临床价值

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目的 探讨树突表达特异性7跨膜蛋白(DCSTAMP)在甲状腺癌(THCA)中的表达及临床价值,旨在为THCA的诊断和治疗提供新思路。方法 使用不同的在线软件,分析DCSTAMP在THCA中的表达水平及其对免疫浸润、临床分期、肿瘤干性、预后的影响,并对其相关差异表达基因及基因本体功能和京都基因与基因组百科全书信号通路富集进行分析。结果 在THCA组织中,DCSTAMP显著过表达,且其表达水平与THCA免疫浸润、临床分期和肿瘤干性呈显著正相关,但对THCA预后无显著影响。DCSTAMP参与THCA发生发展的多种生物学行为。结论 DCSTAMP促进THCA的发生发展,有望成为THCA诊断和治疗的靶点。
Expression and clinical value of DCSTAMP in thyroid carcinoma
Objective To investigate the expression and clinical value of dendrocyte expressed seven transmembrane protein(DCSTAMP)in thyroid carcinoma(THCA),in order to provide new ideas for the diagnosis and treatment of THCA.Methods Using different kinds of online software,the expression level of DCSTAMP in THCA and its influence on immune infiltration,clinical staging,tumor dryness and prognosis were analyzed,and the related differentially expressed genes,gene ontology and Kyoto encyclopedia of genes and genomes signaling pathway enrichment were also analyzed.Results DCSTAMP was significantly overexpressed in THCA tissues,and its expression level was positively correlated with immune infiltration,clinical stage and tumor dryness of THCA,but it had no significant effect on the prognosis of THCA.DCSTAMP was involved in many biological behaviors of the occurrence and development of THCA.Conclusion DCSTAMP promotes the occurrence and development of THCA and has the potential to be the target of diagnosis and treatment of THCA.

Dendrocyte expressed seven transmembrane proteinThyroid carcinomaBioinformatics analysisDiagnosis and treatment

黄荣、郑文斌、崔胜金、刘青、王静、郭伟权、周义文

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南方医科大学深圳医院医学检验科,广东 深圳 518000

树突表达特异性7跨膜蛋白 甲状腺癌 生物信息学分析 诊断和治疗

2024

中国医药科学
海峡两岸医药卫生交流协会 二十一世纪联合创新(北京)医药科学研究院

中国医药科学

影响因子:1.083
ISSN:2095-0616
年,卷(期):2024.14(19)