The value of exfoliative cytology and tumor marker detection in the diagnosis of malignant pleural effusion
Objective To study the value of exfoliative cytology and tumor marker detection in the diagnosis of malignant pleural effusion.Methods A retrospective analysis was conducted on the clinical data of 32 patients with malignant pleural effusion and 45 patients with benign pleural effusion admitted to the Binzhou Medical University Hospital from December 2021 to March 2023.Exfoliative cytology was performed on all patients,and the expression levels of carcinoembryonic antigen(CEA),neuron specific enolase(NSE),and cytokeratin 19 fragment(CYFRA21-1)in the pleural effusion of the two groups of patients were detected and compared;Analysis was made on the diagnostic efficacy evaluation of individual detection of various indicators and combined detection with exfoliative cytology.Results The positive rate of exfoliated cell test was 65.6％.The levels of CEA,NSE,and CYFRA21-1 were higher in the malignant pleural effusion group than in the benign pleural effusion group,and the differences were statistically significant(P＜0.05).The sensitivity and accuracy of combined exfoliative cell morphology examination with CEA,NSE,and CYFRA21-1 in diagnosing malignant pleural effusion were 90.6％and 83.1％,which were higher than the single detection results of CEA,NSE,and CYFRA21-1,and the difference was statistically significant(P＜0.05).The missed diagnosis rate was 9.3％,which was lower than the single test results of CEA,NSE,and CYFRA21-1,and the difference was statistically significant(P＜0.05).There was no statistically significant difference(P＞0.05)in the specificity and misdiagnosis rate of joint testing compared to the results of single tests such as CEA,NSE,and CYFRA21-1.Conclusion Exfoliative cytology examination is an effective method for distinguishing malignant pleural effusion.The combined detection of cell morphology and tumor markers in pleural effusion can significantly improve the sensitivity and accuracy of differential diagnosis of malignant pleural effusion,and reduce the missed diagnosis rate.
万方数据
维普
