Research progress of aromatase inhibitor combined with recombinant human growth hormone in the treatment of adolescent boys with large bone age and short stature
With limited remaining epiphyseal growth space in adolescent boys with large bone age and short stature and predicted short adult height,traditional treatment plans are not as effective in improving height. Consequently,treating such children to achieve normal or target height is more challenging. In recent years,the combination of aromatase inhibitors and recombinant human growth hormone therapy has shown some effectiveness in increasing the height of adolescents with large bone age and short stature,and there have been no serious adverse reactions during treatment. On the basis of analyzing the mechanism of action of aromatase inhibitors,this study provides a review of the effectiveness and safety of using letrozole alone or anastrozole in combination with recombinant human growth hormone to treat height in adolescent boys with large bone age and short stature. The aim is to open up new ideas for the treatment of this type of child and provide valuable references for the formulation and improvement of clinical treatment plans for this disease.
LetrozoleAnastrozoleRecombinant human growth hormoneAdolescents with large bone ageShort statureBoysReview
万方数据
维普
