Application of Remimazolam in anesthesia for endovascular therapy in cerebral infarction and its preventive and therapeutic effects on postoperative delirium
Objective To observe the application of Remimazolam in anesthesia for endovascular therapy (EVT) for cerebral infarction and its preventive and therapeutic effects on postoperative delirium. Methods This study was a prospective study. 125 patients with cerebral infarction who were admitted to the First Affiliated Hospital of Xinxiang Medical University from January 2021 to July 2023 were selected as the study subjects,and were randomly divided into a conventional group (62 cases) and an experimental group (63 cases) using computer randomization. All patients were treated with EVT,with the conventional group receiving conventional general anesthesia and the experimental group receiving Remimazolam as adjuvant anesthesia. The changes in γ-aminobutyric acid (GABA) receptor,cognitive function immediately after awakening,incidence of postoperative delirium,and recovery status of the two groups of patients were compared. Results The GABA level in the experimental group were lower than those in the conventional group at 12,24 and 48 h after operation,and the differences were statistically significant (P<0.05). The scores of mini-mental state examination (MMSE) and Montreal cognitive assessment (MoCA) in the experimental group were higher than those in the conventional group,and the differences were statistically significant (P<0.05). The incidence of postoperative delirium and Ramsay sedation scale (RSS) in the experimental group were lower than those in the conventional group,and the differences were statistically significant (P<0.05). The recovery time after operation and the stay time in the post-anesthesia care init (PACU) in the experimental group were slightly longer than those in the conventional group,with no statistically significant difference (P>0.05). Conclusion Remimazolam can improve immediate postoperative cognitive function in patients and reduce the risk of postoperative delirium by inhibiting GABA activity.
万方数据
维普
