Predictive value of VEGF-C,SDF-1 and S1P on major adverse cardiovascular events in patients with chronic heart failure
Objective To investigate the predictive value of vascular endothelial growth factor C (VEGF-C),stromal cell-derived factor-1(SDF-1) and sphingosine 1-phosphate (S1P) on major adverse cardiovascular events (MACE) in patients with chronic heart failure (CHF). Methods A total of 149 CHF patients admitted to and treated in Central People's Hospital of Zhanjiang from January 2021 to January 2023 were selected as the research object. According to the occurrence of MACE,patients were divided into the MACE group (n=54) and the control group (n=95). The concentrations of VEGF-C,SDF-1 and S1P between the two groups were detected and compared. Binary logistic regression analysis was used for multivariate analysis,and ROC curve was used to evaluate the value of predicting MACE in CHF patients. Results The levels of VEGF-C and S1P in the MACE group were lower than those in the control group,while the level of SDF-1 was higher than that in the control group,with statistically significant difference (P<0.05). Both VEGF-C and S1P are independent protective factors for MACE in CHF patients,while SDF-1 is an independent risk factor for MACE in CHF patients (P<0.05). The 1-AUC detected separately by VEGF-C and S1P were 0.806 and 0.811,respectively,while that of SDF-1 was 0.844,and the joint AUC of three parties of VEGF-C,SDF-1 and S1P was 0.938 (P<0.01). Conclusion VEGF-C,SDF-1 and S1P are influencing factors of MACE in CHF patients,and they all have certain value in the prediction of MACE,in which the combined detection of the three indices has the highest prediction efficiency.
万方数据
维普
