Exploration of the value of albumin-bilirubin score combined with baseline rectal MRI in predicting the distant effect of radiotherapy for liver metastasis of rectal cancer
Objective To explore the prognostic risk factors for survival of liver metastases in rectal cancer after radiotherapy based on the albumin-bilirubin (ALBI) grade combined with baseline rectal MRI. Methods A total of 29 eligible patients with advanced rectal cancer who underwent concurrent radiotherapy or chemotherapy at Longyan First Affiliated Hospital of Fujian Medical University from December 2014 to December 2021 were collected. Laboratory tests and rectal MRI were used as baseline data before treatment,and the evaluation endpoint was progression free survival (PFS). SPSS software was used to evaluate the baseline data and Cox regression analysis. Results The median follow-up time of patients was 26 months. There were 19 cases (65.52％) in the liver metastasis progression group and 10 cases (34.48％) in the non-progression group. There was significant difference in rectal cancer regression grade (RCRG) between the two groups after radiotherapy for rectal cancer (P=0.012). The progression-free survival time in the negative group of extramural venous invasion (EMVI) was longer than that in the positive group (P=0.006). The higher the RCRG grading of rectal cancer after radiotherapy,the shorter the progression-free survival time (P=0.017). In univariate Cox regression analysis,the baseline length and EMVI of rectal cancer were independent factors of treatment response (P=0.027,0.006). A multi-factor clinical model was constructed based on ALBI score. The ALBI score,the baseline length of rectal cancer,EMVI and the baseline T stage of rectal cancer were statistically significant (P<0.05). The area under the curve (AUC) of receiver operating characteristic curve (ROC) of the model was 0.841 (P<0.001,95％CI:0.650-0.952). Conclusion ALBI combined with baseline rectal MRI length,EMVI and T staging has predictive value for the prognosis of liver metastasis of rectal cancer,which is worth further discussion in future research.
万方数据
维普
