Effects of different concentrations of capsaicin solution for nebulization in patients with disorders of consciousness undergoing tracheotomy
Objective To investigate the effects of different concentrations(31.2,62.5,and 125.0 μ mol/L)of capsaicin solution for nebulization in patients with disorders of consciousness(DoC)undergoing tracheotomy.Methods A total of 90 patients with DoC undergoing tracheotomy admitted to the Department of Craniocerebral Injury Rehabilitation of Guangdong Work Injury Rehabilitation Hospital from January 2023 to March 2024 were selected for the study,and were divided into three groups using random number table,with 30 patients in the low concentration group,30 patients in the medium concentration group and 30 patients in the high concentration group.Capsaicin solution for nebulization was administered to patients in the low concentration group(31.2 µ mol/L),medium concentration group(62.5 μ mol/L)and high concentration group(125.0 μ mol/L)through continuous inhalation by high-flow oxygen-driven nebulization at 8 L/min.Results After the intervention,the visual analogue scale(VAS)for cough reflex sensitivity and coma recovery scale-revision(CRS-R)scores were higher in the medium concentration group and high concentration group than those in the low concentration group,with statistically significant differences(P＜0.05).The cough reflex sensitivity VAS and CRS-R scores were higher in the high concentration group than those in the medium concentration group,with statistically significant differences(P＜0.05).The improvement rate of swallowing function was higher in the high concentration group than that in the medium concentration group,with a statistically significant difference(P＜0.05).At the time of nebulization,vital signs in all three groups were within manageable limits with no serious adverse reaction observed.Conclusion Nebulized inhalation of appropriate capsaicin concentration can effectively improve the cough reflex sensitivity in patients with DoC undergoing tracheotomy,and improve patients'swallowing function and consciousness status.The effect of high concentration(125.0 μ mol/L)of capsaicin solution is more ideal than that of low(31.2 μ mol/L)and medium(62.5 µ mol/L)concentrations,with a certain degree of safety.
Disorders of consciousnessTracheotomyCapsaicinExpectoration capacitySwallowing function
万方数据
维普
