Investigation on pathogenesis and complications of early-onset type 2 diabetes mellitus
Patient with type 2 diabetes mellitus(T2DM)whose first diagnosis is under 40 years old is called early-onset type 2 diabetes(EOD).In recent years,patients with T2DM have proliferated in the world,and the age of first diagnosis is getting younger.Compared with late-onset T2DM,the influence of unhealthy lifestyle and genetic factors on EOD patients is more obvious.EOD patients have worse blood glucose control,more severe insulin resistance,faster failure of β-cell function,and higher risk of various microvascular and macrovascular complications associated with diabetes,which leads to higher risk of frequently-occurring diseases and early death in the future.EOD is one of the public health problems worthy of attention.The research on the epidemiological characteristics,pathogenesis and microvascular and macrovascular complications of EOD can provide an important reference for early prevention and treatment of EOD.It reduces the occurrence of EOD,decreases and delays the occurrence and development of its complications,prolongs the life expectancy of EOD patients,improves their quality of life,lowers their medical expenses and alleviates the medical burden of the whole society.
Early-onset type 2 diabetes mellitusPathogenesisMicrovascular diseaseMacrovascular disease
万方数据
维普
