Research on the function mechanism of Mongolian medicine Anaer Siwei Powder in the treatment of functional dyspepsia
Objective To investigate the potential function mechanism in the treatment of functional dyspepsia(FD)with the method of network pharmacology and molecular docking.Methods In this research,the main active components of Anaer Siwei Powder were screened through database and literature mining of Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP),and the function targets of the main active components were predicted and screened by PharmMapper server and GeneCards database.With the help of Gephi,a drug-active ingredient-key target network was constructed,and the obtained target information was enriched and analyzed by GlueGO.The protein interaction network was drawn by using String database and Cytoscape software,and the active components of Anaer Siwei Powder were molecularly docked with the target through Ledock,and the binding activity was analyzed.Results A total of 57 active components of Anaer Siwei Powder were collected,in which Pipernonaline,Sylvatine,Retrofractamide-B,Alnusone and Quercetin were the key components.In the predicted 196 targets,there are 46 repeated targets related to FD,in which albumin(ALB),mitogen-activated protein kinase(MAPK1,MAPK14,MAPK8),estrogen receptor 1(ESR1),epidermal growth factor receptor(EGFR)and caspase-3(CASP3)were the key function targets.These key targets were significantly enriched in biological processes such as mitogen-activated protein kinase(MAPK)activity,nitric oxide synthase regulation activity,response to estrogen stimulation,cyclin-dependent kinase activity regulation,vascular endothelial cell proliferation and so on,and signal transduction of epithelial cells infected by Helicobacter pylori,receptor protein tyrosine kinase signal pathway,estrogen signal pathway and so on.Molecular docking verifies the accuracy of the previous prediction results from the computer simulation level.Conclusion The Mongolian medicine Anaer Siwei powder may play a therapeutic role on FD through anti-inflammation,anti-Helicobacter pylori infection,protection of gastrointestinal mucosa,regulation of gastrointestinal motility and regulation of estrogen level.
Mongolian medicine Anaer Siwei PowderFunctional dyspepsiaNetwork pharmacologyFunction mechanism
万方数据
维普
