Objective To investigate the effectiveness and safety of oral spironolactone combined with topical minoxidil in the treatment of androgenetic alopecia in women.Methods A total of 160 female patients with confirmed androgenetic alopecia admitted to the outpatient clinic of the Department of Dermatology of the Longyan First Affiliated Hospital of Fujian Medical University between September 2021 and December 2022 were selected,and were divided into two groups using the randomized touching ball method.80 patients in the control group were treated with minoxidil monotherapy,and 80 patients in the study group were treated with combined spironolactone on the basis of the treatment in the control group,with a treatment duration of 12 months for both groups.The average hair density of both groups was compared,and the occurrence of adverse events in both groups was recorded.The quality of life of both groups was evaluated using the World Health Organization Quality of Life-100 items(WHOQOL-100)before treatment and at 12 months after treatment.Results After the intervention,the average hair density of both groups was higher than that before the intervention,and the density was higher in the study group than that in the control group,with a statistically significant difference(P＜0.05).The total incidence rate of adverse events was higher in the study group than in the control group,with a statistically significant difference(P＜0.05).After the intervention,the WHOQOL-100 score of both groups was higher than that before the intervention,and the score was higher in the study group than that in the control group,with a statistically significant difference(P＜0.05).Conclusion Oral spironolactone combined with topical minoxidil for the treatment of androgenetic alopecia in women shows high clinical effectiveness and safety,which helps to improve patients'quality of life.
关键词
螺内酯/米诺地尔/雄激素性脱发/有效性/安全性/生活质量
Key words
Spironolactone/Minoxidil/Androgenetic alopecia/Effectiveness/Safety/Quality of life
维普
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