Predictive value of serum β2-microglobulin combined with cystatin-C in contrast-induced nephropathy after percutaneous coronary intervention
Objective To investigate the clinical significance of serum β2-microglobulin(β2-MG)combined with cystatin-C(Cys-C)in predicting contrast-induced nephropathy(CIN)after percutaneous coronary intervention(PCI).Methods A total of 120 patients with mild or moderate renal impairment who underwent PCI in Guangxi Zhuang Autonomous Region Ethnic Hospital from August 2020 to July 2022 were selected as the research objects.Serum creatinine(SCr),β2-MG and Cys-C were detected before and after PCI,glomerular filtration rate(Egfr)was estimated,and the ratios of SCr/β2-MG,SCr/Cys-C and β2-MG/Cys-C were calculated.According to the changes of SCr before and after PCI operation,patients were divided into the non-CIN group and the CIN group.By analyzing the differences of serum β2-MG and Cys-C between the two groups of patients,the predictive value of CIN after PCI operation was analyzed.Results The incidence of CIN was 19.17％(23/120).Before operation,there was no statistically significant difference in Egfr between the CIN group and the non-CIN group(P＞0.05).Serum β2-MG and Cys-C levels in the CIN group were obviously higher than those in the non-CIN group,and the ratio of β2-MG/Cys-C before operation was obviously higher than that in the non-CIN group,with statistically significant differences(P＜0.05).It was shown by Pearson correlation analysis that postoperative SCr was positively correlated with preoperative β2-MG,Cys-C and β2-MG/Cys-C(P＜0.05),and it was negatively correlated with preoperative Egfr,SCr/β2-MG ratio and SCr/Cys-C ratio(P＜0.05).It was indicated by multivariate logistic regression analysis that the increase of preoperative β2-MG/Cys-C ratio was a risk factor for CIN after PCI operation(Oβ=15.988,P＜0.05).The area under ROC curve(AUC)value of preoperative β2-MG,SCr and β2-MG/SCr combined to predict CIN after PCI was 0.900(95％CI:0.845-0.955),and the AUC value of preoperativeβ2-mg/SCR was 0.544,0.520 and 0.672,respectively.Conclusion Serum β2-MG and Cys-C are used as early biomarkers to evaluate the renal function of CIN patients,and the combined use can improve the prediction accuracy of CIN after PCI operation.
万方数据
维普
