Correlation between left ventricular ejection fraction and cerebral white matter hyperintensity in patients with ischemic stroke
Objective To investigate the correlation between left ventricular ejection fraction(LVEF)and the severity of cerebral white matter hyperintensity(WMH)in elderly patients with ischemic stroke,thereby guiding its clinical prevention.Methods A total of 241 elderly patients with ischemic stroke admitted to the Department of Rehabilitation Medicine of Tangdu Hospital of Air Force Medical University from August 2022 to December 2023 were retrospectively selected as study subjects.The patients were divided into high-grade white matterhyperintensity(HWMH)group(n=136)and non-HWMH group(n=105)according to the fazekas score,and the differences in clinical data between the two groups were analyzed.Factors influencing HWMH were analyzed using multifactorial logistic regression.The predictive value was assessed by receiver operating characteristic(ROC)curve.Results The proportion of hypertension,uric acid,and C-reactive protein(CRP)levels were significantly higher and the LVEF value was significantly lower in the HWMH group compared with the non-HWMH group,with statistically significant differences(P＜0.05).Multifactorial logistic regression analysis showed that hypertension,CRP,and LVEF were independent risk factors of HWMH(P＜0.05).The area under the ROC curve of LVEF for predicting HWMH in patients with ischemic stroke was 0.710(95％CI:0.645-0.774,P＜0.001).Conclusion LVEF in patients with ischemic stroke has a certain predictive value for the severity of WMH,which provides clues for further study on the pathophysiological mechanisms of WMH.
Ischemic strokeCerebral white matter hyperintensityLeft ventricular ejection fractionHypoperfusion
万方数据
维普
