Effects of two endometrial preparation regimens on pregnancy outcomes of frozen embryo transfer in postoperative patients with uterine adhesions
Objective To compare the effects of hormone replacement therapy(HRT)regimen and ovulation induction(OI)regimen on pregnancy outcomes of frozen-thawed embryo transfer in patients after surgery for intrauterine adhesions(IUA).Methods A total of 102 postoperative IUA patients who underwent frozen-thawed embryo transfer in the Center of Reproductive Medicine of Maternal and Child Health Hospital of Kunming from January 2021 to December 2022 were selected.They divided into the live birth group(n=39)and the non-live birth group(n=63)according to the pregnancy outcome.Clinical data of patients in the two groups and differences between the two endometrial preparation regimens were compared.Logistic regression analysis was further performed on factors affecting the pregnancy outcome.Results Comparison of age,body mass index(BMI),basal hormone levels(follicle-stimulating hormone[FSH],luteinizing hormone[LH],and estradiol[E2]),the number of embryos transferred,and the number of high qualified embryos between the two groups showed no statistically significant difference(P＞0.05).The number of years of infertility was less,and the endometrial thickness on the day of conversion was greater in the live birth group than those in the non-live birth group,and the application of the OI regimen was more likely to result in a high live birth rate than that of the HRT regimen,with statistically significant differences(P＜0.05).Logistic regression analysis showed that endometrial thickness on the day of conversion was an independent protective factor for live birth(P＜0.001).The application of HRT regimen was an independent risk factor(P＜0.05).Conclusion In patients undergoing frozen-thawed embryo transfer after IUA,both the endometrial thickness on the day of conversion and different endometrial preparation regimens can affect pregnancy outcomes.The OI regimen is superior to the HRT regimen in improving pregnancy outcomes.
万方数据
维普
