In recent years,the targeted solute carriers(SLC)family has become a research hotspot in the field of cancer pharmacology and drug discovery.SLC family transporters participate in the transmembrane transport of various solutes(inorganic ions,amino acids,neurotransmitters and drugs)and maintain cell metabolism.Since the Warburg effect was discovered in the 1920s,metabolic reprogramming in cancer cells has been widely accepted.As a sign of cancer progress,metabolic reprogramming provides a research direction for the diagnosis,prognosis and treatment of cancer.The research on SLC family involves the metabolic process of many tumors.However,there are relatively few reports about SLC family in the metabolism of triple-negative breast cancer(TNBC).Therefore,the correlation between the function of SLC family in TNBC metabolism and cancer progression is reviewed,and the SLC targets reported recently are summarized in this paper.
关键词
三阴性乳腺癌/溶质载体家族/代谢/肿瘤
Key words
Triple-negative breast cancer/Solute carriers family/Metabolism/Tumour
维普
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