Research progress of SLC family in triple-negative breast cancer metabolism
In recent years,the targeted solute carriers(SLC)family has become a research hotspot in the field of cancer pharmacology and drug discovery.SLC family transporters participate in the transmembrane transport of various solutes(inorganic ions,amino acids,neurotransmitters and drugs)and maintain cell metabolism.Since the Warburg effect was discovered in the 1920s,metabolic reprogramming in cancer cells has been widely accepted.As a sign of cancer progress,metabolic reprogramming provides a research direction for the diagnosis,prognosis and treatment of cancer.The research on SLC family involves the metabolic process of many tumors.However,there are relatively few reports about SLC family in the metabolism of triple-negative breast cancer(TNBC).Therefore,the correlation between the function of SLC family in TNBC metabolism and cancer progression is reviewed,and the SLC targets reported recently are summarized in this paper.
Triple-negative breast cancerSolute carriers familyMetabolismTumour
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维普
