Impact of preoperative serum Hcy and albumin levels on perioperative anastomotic leakage in patients with esophageal cancer
Objective To investigate the impact of preoperative blood homocysteine(Hcy)and albumin levels on anastomotic leakage in patients with esophageal cancer.Methods In this research,a total of 303 patients who underwent radical resection of esophageal cancer in Taian City Central Hospital from January 2017 to December 2023 were included.The incidence of anastomotic leakage in the early and middle stages after operation was observed.The indices such as gender,age,preoperative serum albumin,blood Hcy,white blood cells,esophageal cancer location,diabetes,coronary heart disease,carotid plaque,enhanced recovery after surgery(ERAS),digestive tract ulcer and calcification of descending aorta were observed,and multivariate logistic analysis was conducted.Results The incidence of anastomotic leakage in the early and middle stages of perioperative esophageal cancer in this group was 8.91％.The results of the univariate analysis showed that there were all statistically significant differences in age,blood albumin,and blood Hcy(P＜0.05).Gender,hemoglobin,white blood cell count,location of esophageal cancer,complicated diabetes,complicated coronary heart disease,complicated carotid plaque,ERAS,digestive tract ulcer,calcification of descending aorta,etc.were not significantly related to the occurrence of anastomotic leakage,without statistically significant differences(P＞0.05).Multifactor logistic analysis results showed that preoperative albumin(OR=0.75,P=0.000)and blood Hcy(OR=1.07,P=0.()10)were independent factors for the occurrence of anastomotic leakage.Conclusion Reducing preoperative blood Hey level and improving hypoalbuminemia are of great significance in reducing the occurrence of anastomotic leakage in early and middle stages of the esophageal cancer perioperative period.
万方数据
维普
