Effect of Xanthoceras sorbifolium Bunge.oil on memory ability of male mice
In order to provide data support for the development of Xanthoceras sorbifolium Bunge.oil related products,healthy male mice were divided into 4 groups,namely control group(corn oil),low-dose group[2.1g/(kg·d)],medium-dose group[4.2 g/(kg·d)]and high-dose group[12.5 g/(kg·d)]of the Xanthoceras sorbifolium Bunge.oil.After one month of intragastric administration,the body weight of mice was measured,and the step-down test,dark avoidance test and water maze test were carried out to evaluate the effects of Xanthoceras sorbifolium Bunge.oil on memory ability of male mice.In addition,the contents of dopamine(DA),5-hydroxytryptamine(5-HT),norepinephrine(NE),acetylcholine(ACh)and the activity of acetylcholinesterase(AChE)in the homogenates of hippocampus and cerebral cortex of mice were measured to explore the mechanism of the effect of Xanthoceras sorbifolium Bunge.oil on memory ability of mice.The results showed that there was no significant difference in body weight and growth rate among all groups after one month of intragastric administration test.The step-down test,dark avoidance test and water maze test were all positive.In high-dose group,the contents of 5-HT,ACh,NE and DA in homogenates of hippocampus and cerebral cortex of mice were significantly increased and the activity of AChE was significantly decreased.In summary,Xanthoceras sorbifolium Bunge.oil has the function of improving memory of mice,and it plays the role by improving the metabolism of monoamine neurotransmitters and cholinergic neurotransmitters.
Xanthoceras sorbifolium Bunge.oilnervonic acidmemory abilitystep-down testdark avoidance testwater maze test
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万方数据
维普
