支链、奇数链脂肪酸与肠道健康的关联性研究
Association between branched/odd-chain fatty acids and intestinal health
张颖 1张杏芳 1闫雨蒙 1沈旖凝 1闫媛媛 1李晓光1
作者信息
- 1. 上海交通大学医学院公共卫生学院,上海 200025
- 折叠
摘要
为明确支链脂肪酸(BCFA)与奇数链脂肪酸(OCFA)对肠道健康的影响,利用气相色谱-质谱联用分析健康人群与肠道疾病患者血液中脂肪酸含量的差异,并应用正交偏最小二乘-判别分析(OPLS-DA)鉴定肠道健康人群的特征脂肪酸.结果表明:健康对照组、肠道息肉组、结直肠癌组3组人群中共检测出9种BCFA和4种OCFA;BCFA、OCFA含量在健康人群中显著偏高(p＜0.05),其中anteiso-C17∶0、C17∶0含量随肠道健康状态恶化呈梯度下降趋势(p＜0.05);OPLS-DA 共鉴定出 anteiso-C17∶0、iso-C17∶0、C18∶1、C18∶0、C16∶0、C14∶0 6 种特征脂肪酸标志物.综上,BCFA和OCFA对肠道健康有潜在的保护作用.
Abstract
To ascertain the effects of branched-chain fatty acids(BCFA)and odd-chain fatty acids(OCFA)on intestinal health,serum fatty acid contents in healthy population and patients with intestinal diseases were measured by gas chromatography-mass spectrometry.Orthogonal partial least-squares discrimination analysis(OPLS-DA)was used to identify characteristic fatty acid of intestinal healthy population.The results showed that 9 kinds of BCFA and 4 kinds of OCFA were detected in the healthy control group,intestinal polyp group and colorectal cancer group.The contents of BCFA and OCFA were significantly higher in healthy population(p＜0.05),and the contents of anteiso-C17∶0 and C17∶0 showed a gradient decreasing trend with the deterioration of intestinal health status(p＜0.05).OPLS-DA identified six characteristic fatty acid markers of anteiso-C17∶0,iso-C17∶0,C18∶1,C18∶0,C16∶0 and C14∶0.To sum up,BCFA and OCFA have a potential protective effect on intestinal health.
关键词
支链脂肪酸/奇数链脂肪酸/肠道健康Key words
branched-chain fatty acids/odd-chain fatty acids/intestinal health引用本文复制引用
基金项目
国家自然科学基金面上项目(81972820)
出版年
2024
NETL
NSTL
万方数据