血浆纤维蛋白原/血清白蛋白比值与急性脑梗死患者脑动脉狭窄程度的关系
Relationship between plasma fibrinogen/serum albumin ratio and the degree of cerebral artery stenosis in patients with acute cerebral infarction
杨睿杰 1何阳 1李丽娟 1王俊杰 1桂英 1马琳1
作者信息
- 1. 海南医学院第一附属医院神经内科,海口 570102
- 折叠
摘要
目的 探讨血浆纤维蛋白原/血清白蛋白比值(fibrinogen-albumin ratio,FAR)与急性脑梗死(acute cerebral infarct,ACI)患者脑动脉狭窄程度之间的关系.方法 选取2021年1月至2023年3月在海南医学院第一附属医院神经内科诊治的急性脑梗死189例患者的临床资料进行回顾性分析,完善数字减影血管成像(digital subtraction angiography,DSA),按照北美症状性颈内动脉内膜剥脱试验法(North American Symptomatic Carotid Endarterectomy,NASCET)分级方法,根据颅内血管狭窄程度将其分为4组:无狭窄组(47例)、轻度狭窄组(45例)、中度狭窄组(39例)和重度狭窄及闭塞组(58例),比较各组基本资料、炎性指标的差异,分析FAR和脑动脉狭窄程度的关系,采用多因素Logistic回归探索影响脑动脉狭窄的因素,ROC曲线评价FAR对脑梗死患者脑动脉狭窄程度的诊断价值.结果 4组脑梗死患者血中性粒细胞计数、平均血小板体积、白蛋白、纤维蛋白原及FAR组间比较,差异均有统计学意义(统计量值分别为H=11.50、H=8.44、F=5.16、H=30.93、H=40.38;均P＜0.05).相关性分析显示,FAR和脑动脉狭窄程度呈正相关(r=0.455,P＜0.05).多因素Logistic回归显示,FAR是导致脑动脉狭窄程度变化的独立危险因素(OR=1.445,95％CI:1.261～1.655,P＜0.001).结论 FAR为ACI患者脑动脉狭窄程度的独立危险因素,可能成为预测脑动脉狭窄的新型生物标志物.
Abstract
Objective To investigate the correlation between plasma fibrinogen/serum albumin ratio(FAR)and the degree of cerebral artery stenosis in patients with acute cerebral infarction(ACI).Methods Clinical data of 189 patients with acute cerebral infarction diagnosed and treated in the Department of Neurology of the First Affiliated Hospital of Hainan Medical College from January 2021 to March 2023 were selected for retrospective analysis.Digital subtraction angiography(DSA)was improved,and they were divided into four groups according to the degree of intracranial vascular stenosis according to NASCET grading method:no stenosis group(47 cases),mild stenosis group(45 cases),moderate stenosis group(39 cases)and severe stenosis and occlusion group(58 cases).The differences of basic data,plasma fibrinogen/serum albumin ratio(FAR)and other inflammatory indicators among all groups were compared,and the correlation between FAR level and the severity of cerebral artery stenosis was analyzed.Multivariate Logistic regression was used to explore the factors influencing to cerebral artery stenosis and ROC curve was used to evaluate the diagnostic value of FAR in the degree of cerebral artery stenosis in cerebral infarction patients.Results There were significant differences in blood neutrophil(NEU),mean platelet volume(MPV),fibrinogen(FIB),fibrinogen(FIB),albumin(ALB)and FAR among the 4 groups(statistical values were H=11.50,H=8.44,F=5.16,H=30.93,H=40.38;all P＜0.05).Correlation analysis showed a positive correlation between FAR and the degree of cerebral artery stenosis(r=0.455,P＜0.05).Multivariate Logistic regression showed that FAR was an independent risk factor for the degree of cerebral artery stenosis(OR=1.445,95％CI=1.261-1.655,P＜0.001).Conclusion FAR is an independent risk factor for cerebral artery stenosis in patients with acute cerebral infarction(ACI),and may be a new biomarker for predicting cerebral artery stenosis.
关键词
脑梗死/颅内动脉粥样硬化/纤维蛋白原/白蛋白Key words
Cerebral infarction/Intracranial atherosclerosis/Fibrinogen/Albumin引用本文复制引用
基金项目
海南省自然科学基金青年基金(821QN0987)
出版年
2024
NETL
NSTL
万方数据