Multi-course Iodine-131-meta-iodobenzylguanidine in the treatment of metastatic paraganglioma: a case report
李赟 1高洪波 1李隆敏 1邵玉军 1祝夏阳 1苗丽娟
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作者信息
1. 北京核工业医院核素诊疗中心，北京 102413
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摘要
副神经节瘤（paraganglioma，PGL）是一种引起内分泌性高血压的少见神经内分泌肿瘤，所有副神经节瘤均具有转移潜能。转移性副神经节瘤患者5年存活率<50%，治疗是较大的难题。转移性PGL对碘［131I］-间碘苄胍（131I-meta-iodobenzylguanidine，131I-MIBG）具有较高的特异性摄取，因此治疗效果佳、耐受性良好、不良反应少，但目前国内暂缺少相关详细临床诊疗数据。现报道1例多部位转移性副神经节瘤多疗程131I-MIBG详细诊治经过，并探讨其治疗效果、安全及耐受性，供临床参考。 Paraganglioma (PGL) is a rare neuroendocrine tumor that causes endocrine hypertension. All paragangliomas had metastatic potential. The 5-year survival rate of patients with metastatic paraganglioma is less than 50%, and the treatment is a big problem. Metastatic PGL has a high specific uptake of iodine [131I]-meta-iodobenzylguanidine (131I-MIBG), so the treatment is effective, well tolerated, and has few adverse reactions. However, there is a lack of relevant detailed clinical diagnosis and treatment data in China. This article reports the diagnosis and treatment of a case of multi-site metastatic paraganglioma with multiple courses of 131I-MIBG, and discusses the efficacy, safety and tolerance of the treatment for clinical reference.
Abstract
Paraganglioma (PGL) is a rare neuroendocrine tumor that causes endocrine hypertension. All paragangliomas had metastatic potential. The 5-year survival rate of patients with metastatic paraganglioma is less than 50%, and the treatment is a big problem. Metastatic PGL has a high specific uptake of iodine [131I]-meta-iodobenzylguanidine (131I-MIBG), so the treatment is effective, well tolerated, and has few adverse reactions. However, there is a lack of relevant detailed clinical diagnosis and treatment data in China. This article reports the diagnosis and treatment of a case of multi-site metastatic paraganglioma with multiple courses of 131I-MIBG, and discusses the efficacy, safety and tolerance of the treatment for clinical reference.
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