Anti-cancer strategies from the perspective of protein homeostasis and their clinical implications
Protein conformation is susceptible to cellular proteomic stresses,such as pathogenic mutations and environmental stresses.Protein homeostasis maintains a delicate balance of the functional folding of proteins in response to these stresses by regulating protein synthesis,folding,post-translational modification and intracelluar degradation.Imbalances in protein homeostasis lead to the aggregation and accumulation of misfolded proteins,which constitute hallmark events of protein conformational diseases,including certain types of cancers and neurodegenerative diseases.Tumor cells are highly dependent on protein homeostasis,and dysfunctional cancer proliferation and metastasis often require rapid protein synthesis and adequate downstream quality control capabilities.Overloaded synthesis in tumor cells exceeds the capacity of the protein homeostasis network,leading to defects in protein conformation.Intervening in protein homeostasis has thus been shown to be a promising therapeutic strategy against cancer.This paper reviews anti-tumor strategies from the perspective of protein homeostasis and discusses their clinical implications.
Protein homeostasisNeoplasmsProtein conformationAutophagy
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