Research progress on BMP-2 derived peptide in promoting osteogenesis
Scaffold materials have been applied as autologous bone substitutes in surgical procedures for repairing bone defects caused by bone tumors,trauma,and malignant tumor bone metastases.P24 peptide,as a synthetic short peptide of BMP-2,has similar biological activity to rhBMP-2 and has been proven to promote osteogenesis.P24 peptide has been found to regulate the proliferation and differentiation of bone marrow mesenchymal stem cells,and induce ectopic bone formation in vivo,showing great potential in bone defect repair.This review examines the mechanism by which P24 promotes osteogenic proliferation.
Bone morphogenetic protein 2Derived peptideBone marrow mesenchymal stem cellsOsteogenesis
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