Expressions of Ki-67 and vascular endothelial growth factor receptor 2 and microvascular density in non-small cell lung cancer tissue and their associations with efficacy of apatinib
Objective To investigate the expressions of Ki-67,vascular endothelial growth factor receptor 2(VEGFR-2)and microvascular density(MVD)in non-small cell lung cancer(NSCLC),and their associations with the efficacy of apatinib.Methods Forty-two patients with advanced NSCLC admitted to the Affiliated Tumor Hospital of Harbin Medical University from January 2020 to August 2022 were selected.The expressions of Ki-67,VEGFR-2 and CD34 in tissues of patients were detected by immunohistochemical method,and MVD was measured.The association between expressions of Ki-67,VEGFR-2 with levels of MVD and clinical characteristics of patients were determined.The clinical efficacy of apatinib between different expressions of Ki-67,VEGFR-2 and MVD were also determined.Results The high expression rates of Ki-67,VEGFR-2,and MVD were 52.4％(22/42),69.0％(29/42),and 54.8％(23/42),respectively,with a mean MVD of 22.42 per field.Univariate analysis showed that the degree of tumor differentiation and lymph node metastasis were correlated with high expressions of Ki-67 and high levels of MVD(all P＜0.05).Tumor lymph node metastasis was associated with high expression of VEGFR-2(P＜0.05).Expressions of VEGFR-2,Ki-67 and MVD were not correlated with gender,age,Eastern Cooperative Oncology Group(ECOG)rating,smoking history,pathological type of tumor or extrapulmonary metastasis(all P＞0.05).Multivariate analysis showed that low tumor differentiation(OR=11.265,95％CI:2.948-39.925,P=0.009)was an independent influencing factor for Ki-67 high expression,while lymph node metastasis(OR=8.689,95％CI:1.215-62.122,P=0.031)was an independent influencing factor for VEGFR-2 high expression(all P＜0.05).After the treatment regimen of apatinib,high expression of MVD was associated with high ORR in NSCLC patients,and high expressions of Ki-67,VEGFR-2 and MVD were associated with high DCR in NSCLC patients.Conclusions The degree of tumor differentiation is an independent influencing factor for Ki-67 high expression,and lymph node metastasis is an independent influencing factor for VEGFR-2 high expression.The combined detection of Ki-67,VEGFR-2 and MVD 3 has certain clinical efficacy prediction value in second-line and above apatinib treatment schemes.
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