恶性肿瘤患者肌肉减少症的危险因素及与营养风险筛查2002评分的相关性
Risk factors for sarcopenia in patients with malignant tumours and correlation between sarcopenia and Nutritional Risk Screening 2002 scores
杜海霞 1郑楠 1蒋菊林2
作者信息
- 1. 甘肃省敦煌市医院消化肿瘤科,敦煌 736200
- 2. 甘肃省敦煌市医院普外科,敦煌 736200
- 折叠
摘要
目的 探讨恶性肿瘤患者肌肉减少症(SAR)的相关危险因素,分析营养风险筛查2002(NRS-2002)评分与恶性肿瘤患者SAR的相关性.方法 回顾性分析2020年1月至2023年11月敦煌市医院收治的230例恶性肿瘤患者临床资料,根据亚洲肌肉减少症工作组(AWGS)诊断标准对其分组.采用NRS-2002量表评估营养风险,对其并发SAR的相关影响因素进行logistic回归分析.采用Spearson相关分析法分析患者并发SAR与NRS-2002评分的相关性.结果 230例患者中,SAR 120例,非SAR 110例;存在营养风险105例,无营养风险125例.单因素分析显示,体质指数(BMI)、基础代谢率(BMR)、内脏脂肪面积(VFA)、白蛋白(ALB)、前白蛋白(PA)、总蛋白(TP)和NRS-2002评分与SAR发生有关(均P＜0.05),年龄、性别、肿瘤分期、治疗方式、腰围(WC)、血红蛋白(Hb)与SAR发生无关(均P＞0.05).多因素logistic回归分析结果显示,BMI低(OR=0.684,95％CI:0.520～0.879,P=0.003)、BMR 低(OR=0.702,95％CI:0.133～3.735,P=0.010)、VFA 低(OR=0.506,95％CI:0.124～2.053,P=0.023),NRS-2002 评分高(OR=1.765,95％CI:1.015～3.113,P=0.017)是恶性肿瘤患者并发SAR的独立危险因素.Spearson相关分析结果显示,恶性肿瘤患者并发SAR与NRS-2002评分呈正相关(r=0.558,P＜0.001).结论 恶性肿瘤患者BMI、BMR、VFA越低,NRS-2002评分越高,SAR发生风险也越高,恶性肿瘤患者SAR发生与恶性肿瘤患者较高的NRS-2002评分呈正相关.
Abstract
Objective To investigate risk factors associated with sarcopenia(SAR)in patients with malignancy and to analyse the correlation between Nutritional Risk Screening 2002(NRS-2002)scores and SAR in patients with malignancy.Methods The clinical data of 230 patients with malignant tumours admitted to Dunhuang City Hospital from January 2020 to November 2023 were analysed retrospectively.All patients were grouped according to the diagnostic criteria of the Asian Working Group on Sarcopenia(AWGS).Nutritional risk was assessed with the NRS-2002 scale,and logistic regression analyses were carried out to analyse the influencing factors related to concomitant SAR.Spearson's correlation analysis was used to analyse the correlation between patients'concurrent SAR and NRS-2002 scores.Results Among the 230 patients,there were 120 SAR cases and 110 non-SAR cases,105 cases with nutritional risks and 125 cases without nutritional risks.Univariate analyses showed that body mass index(BMI),basal metabolic rate(BMR),visceral fat area(VFA),albumin(ALB),prealbumin(PA),total protein(TP),and NRS-2002 scores were correlated with SAR(all P＜0.05),while age,gender,cancer staging,mode of treatment,waist circumference(WC)and hemoglobin(Hb)were not correlated with SAR(P＞0.05).Multivariate logistic regression analyses showed that low BMI(OR=0.684,95％CI:0.520～0.879,P=0.003),low BMR(OR=0.702,95％CI:0.133～3.735,P=0.010),low VFA(OR=0.506,95％CI:0.124～2.053,P=0.023),and high NRS-2002 scores(OR=1.765,95％CI:1.015～3.113,P=0.017)were independent risk factors for concurrent SAR in patients with malignant tumours(P＜0.05).Spearson's correlation analysis showed a significant positive correlation between concurrent SAR and NRS-2002 score in patients with malignant tumours(r=0.558,P＜0.001).Conclusions The lower BMI,BMR,VFA,and higher NRS-2002 scores increased the risk of SAR occurrence in patients with malignant tumours.The occurrence of SAR was positively correlated with NRS-2002 scores in patients with malignant tumours.
关键词
营养风险筛查/肌肉减少症/恶性肿瘤/营养不良/相关性Key words
Nutritional risk screening/Sarcopenia/Malignancy/Malnutrition/Correlation引用本文复制引用
出版年
2024
NETL
NSTL
万方数据