糖酵解调节与代谢关键调控因子沉默信息调节因子1在肿瘤细胞中的作用
Role of glycolysis regulation and key metabolic regulator SIRT1 in tumor cells
牛雅茹 1杨文蔚 1方宇婷 1向密丹 1钱海利 2孙永琨1
作者信息
- 1. 国家癌症中心国家肿瘤临床医学研究中心中国医学科学院北京协和医学院肿瘤医院内科,北京 100021
- 2. 国家癌症中心国家肿瘤临床医学研究中心 中国医学科学院北京协和医学院肿瘤医院分子肿瘤学国家重点实验室,北京 100021
- 折叠
摘要
糖酵解在肿瘤细胞的增殖、侵袭和转移中起关键作用.通过Warburg效应,肿瘤细胞能够产生满足细胞生长所需的能量和生物大分子物质.糖酵解的关键调节因子包括葡萄糖转运蛋白(GLUT)和一系列酶,如己糖激酶(HK)、丙酮酸激酶M2型(PKM2)、甘油醛-3-磷酸脱氢酶(GAPDH)、乳酸脱氢酶(LDH)、单羧酸转运蛋白1(MCT1)和单羧酸转运蛋白4(MCT4)等,这些调节因子的转录调控对于糖酵解途径中的信号传导非常重要.此外,沉默信息调节因子1(SIRT1)作为一种关键的去乙酰化酶,通过调控基因表达和蛋白质翻译后修饰参与多种恶性肿瘤途径,包括代谢重编程过程.文章综述了糖酵解在肿瘤中的关键蛋白和酶的作用及其调节机制,并探讨了 SIRT1的调控作用,进一步探讨肿瘤细胞糖酵解与SIRT1可能的联动以及未来的研究方向.
Abstract
Glycolysis plays a crucial role in the proliferation,invasion,and metastasis of tumor cells.Through the Warburg effect,tumor cells can generate the energy and biomolecules required for cell growth.Key regulatory factors of glycolysis include glucose transporters and a series of enzymes,such as GLUT,HK,PKM2,GAPDH,LDHA,and MCT1/4.The transcriptional regulation of these factors is vital for signal transduction within the glycolytic pathway.Additionally,SIRT1,as a key deacetylase,participates in various malignant tumor pathways by regulating gene expression and post-translational modifications of proteins,including metabolic reprogramming processes.This article reviews the roles of key proteins and enzymes involved in glycolysis in tumors and their regulatory mechanisms,explores the regulatory role of SIRT1,and further investigates the potential interplay between tumor cell glycolysis and SIRT1,as well as future research directions.
关键词
恶性肿瘤/糖酵解/转录调控/沉默信息调节因子1/蛋白质翻译后修饰Key words
Neoplasms/Glycolysis/Transcriptional regulation/Silent information regulator 1,SIRT1/Protein post-translational modifications引用本文复制引用
出版年
2024
NETL
NSTL
万方数据