肺癌脑转移的药物治疗进展
Advancements in drug therapy for brain metastasis of lung cancer
朱以香 1王洁1
作者信息
- 1. 国家癌症中心 国家肿瘤临床医学研究中心 中国医学科学院北京协和医学院肿瘤医院肺癌转化实验室 分子肿瘤学国家重点实验室,北京 100021
- 折叠
摘要
脑转移是肺癌预后较差的一种疾病类型,既往传统化疗时代,缺乏特异性的治疗手段.但随着靶向治疗药物、免疫治疗药物、抗体偶联药物等诸多药物的发展,肺癌的治疗手段更为丰富.上述治疗方式使肺癌脑转移的治疗效果也有了显著提升.基于此,文章从靶向治疗药物、抗体偶联药物及免疫检查点抑制剂等方面对当前治疗肺癌脑转移的药物进展进行概述,梳理并总结目前可用的手段及未来发展方向,希望对肺癌脑转移的治疗有一定参考意义.
Abstract
Brain metastasis is a type of lung cancer with a poor prognosis,and during the era of traditional chemotherapy,there was a lack of specific treatment options.However,with the development of targeted therapies,immunotherapies,and antibody-drug conjugates,treatment options for lung cancer have significantly improved.These advancements have also led to notable progress in the treatment of lung cancer brain metastases.Based on this,the article provides an overview of the current therapeutic developments for lung cancer brain metastasis,focusing on targeted therapies,antibody-drug conjugates,and immune checkpoint inhibitors.It reviews and summarizes the available treatments and future directions,aiming to provide valuable insights for improving the treatment of lung cancer brain metastasis.
关键词
肺癌/肿瘤转移,脑/靶向治疗/抗体偶联药物/免疫检查点抑制剂Key words
Lung neoplasms/Neoplasms metastasis,brain/Targeted therapy/Antibody-drug conjugate/Immune checkpoint inhibitors引用本文复制引用
基金项目
国家重点研发计划(2022YFC2505000)
国家自然科学基金(82272796)
出版年
2024
NETL
NSTL
万方数据