Biological characteristics and clinical treatment advances in pulmonary sarcomatoid carcinoma
Pulmonary sarcomatoid carcinoma(PSC)is a rare and aggressive subtype of non-small cell lung cancer(NSCLC)with a poor prognosis.PSC is characterized by both carcinoma and sarcomatoid components,high genetic mutation rates,and significant immune infiltration.Traditional chemotherapy has limited efficacy in PSC.Recently,targeted therapies have shown better outcomes for PSC patients with specific gene mutations.The high levels of immune infiltration and checkpoint expression in PSC provide a basis for the use of immune checkpoint inhibitors.Immunotherapy and combination treatments have demonstrated promising results.However,more research and clinical trials are urgently needed.This article reviews the biological characteristics of PSC and summarizes the clinical efficacy of various treatments.
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