Clinical effect of the combined treatment of Shuganyangxin Fuzheng Method and mindfulness intervention in the treatment of depression after lung cancer surgery
Objective To investigate the clinical efficiency of Shuganyangxin Fuzheng method combined with mindfulness intervention on depression after lung cancer surgery.Methods From May 2018 to March 2019,a total of sixty-four patients with depression after lung cancer surgery were randomly divided into the treatment group and the control group,32 cases in each group.The control group was treated with Chinese medicine by using Shuganyangxin Fuzheng Method,the treatment group was treated with mindfulness intervention based on the treatment for the control group,with a course of 3 months.The clinical efficacy and the changes of TCM syndrome scores,Zung Depression Self-Assessment(SDS)scores,Hamilton Depression Scale(HAMD)scores,Function Assessment to Cancer Therapy-Lung(FACT-L)scores,levels of T lymphocyte subsets(CD3+、CD4+、CD8+)were observed.Results The overall clinical effective rates were 93.8%(30/32)in the treatment group and 75.0%(24/32)in the control group,and the clinical efficacy of the treatment group was better than that of the control group(χ2=13.55,P=0.001).After treatment,the TCM syndrome scores of the treatment group and the control group were(3.22±1.58)and(5.44±1.37)points,which were significantly lower than before treatment(t=11.38,t=12.90,all P＜0.001),and the TCM syndrome score of the treatment group was significantly lower than that of the control group(t=-6.01,P＜0.001).After treatment,the SDS scores of the treatment group and the control group were(27.88±3.34)and(43.88±5.86)points,which were significantly lower than before treatment(t=14.05,t=7.86,all P＜0.001),and the SDS score of the treatment group was significantly lower than that of the control group(t=-13.42,P＜0.001).After treatment,the HAMD scores of the treatment group and the control group were(11.38±3.55)and(18.56±2.12)points,which were significantly lower than before treatment(t=15.64,t=5.74,all P＜0.001),and the HAMD score of the treatment group was significantly lower than that of the control group(t=-9.84,P＜0.001).After treatment,the total FACT-L scores and scores for physical condition,social and family status,emotional status,functional status,and additional areas of concern in the treatment group and control group were significantly increased compared to before treatment(all P＜0.001).The treatment group had significantly higher FACT-L total scores and scores in other areas,except for social and family status,compared to the control group(all P＜0.001).After treatment,the proportion of CD3+T cells and CD4+T cells in the treatment group increased significantly compared to before treatment(all P＜0.05),but there was no statistically significant difference in the proportion of CD8+T cells and CD4+/CD8+T cells compared to before treatment(all P＞0.05).There was no statistically significant difference in the proportion of CD3+T cells,CD4+T cells,CD8+T cells,and CD4+/CD8+T cells in the control group(all P＞0.05).The proportion of CD3+T cells and CD4+T cells in the treatment group was significantly higher than that in the control group(t=2.08,t=2.67,all P＜0.05).Conclusions Shuganyangxin Fuzheng method can effectively relieve depression of patients after lung cancer surgery,alleviate the clinical symptoms,and improve the quality of life.The combined treatment with mindfulness intervention shows even better efficacy and can further improve patients'immune function.
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