首页|决明山楂燕麦胶囊对综合因素诱导的大鼠脂肪肝的影响

决明山楂燕麦胶囊对综合因素诱导的大鼠脂肪肝的影响

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目的研究复方决明山楂燕麦胶囊对综合因素复制的大鼠脂肪肝的防治作用。方法采用注射10%四氯化碳(CCl4)合并高脂饮食喂养方式建立大鼠脂肪肝模型,以大鼠一般情况、血清丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)含量、肝脏病理改变为评价指标,观察药物的保护作用。结果与模型组比较,决明山楂燕麦胶囊可非常显著降低大鼠血清ALT含量(P〈0.01);显著降低大鼠血清AST含量(P〈0.05);并明显改善脂肪肝模型大鼠的肝脏病理改变,减轻肝脏的脂肪变性。结论决明山楂燕麦胶囊对综合因素诱导的大鼠脂肪肝有防治作用。
The influence of semen cassiae hawthorn oat capsules on fatty liver induced by integrated factors in rats
Objective To research the preventive and therapeutic effects of compound semen cassiae hawthorn oat capsules on fatty liver induced by integrated factors in rats.Methods Model of rats′ fatty liver was established by injection of 10% carbon tetrachloride(CCl4)as well as feeding of high fat diet.The general physical state,levels of serum alanine transaminase(ALT),aspartate transaminase(AST)and hepatic pathological changes were checked in rats to evaluate the protective effect of semen cassiae hawthorn oat capsules.Results Compared with fatty liver model group,the semen cassiae hawthorn oat capsules could very markedly lower the content of ALT(P0.01),markedly lower the contents of the AST(P0.05),obviously ameliorate hepatic pathological changes and lighten hepatic steatosis of fatty liver rat in treated groups.Conclusion The semen cassiae hawthorn oat capsules is effective in preventing and treating fatty liver induced by integrated factors in rats.

HyperlipidemiaFatty liverOatCarbon tetrachlorideFunctional foods

白建平、杨立志、张海飞、尉杰忠、丰玲、马存根

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山西大同大学脑科学研究所,山西大同037009

高脂血症 脂肪肝 燕麦 四氯化碳 保健食品

山西省科技攻关项目

20100321105

2010

中国自然医学杂志
中华预防医学会

中国自然医学杂志

影响因子:0.307
ISSN:1008-7850
年,卷(期):2010.(6)
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