An experimental research on the effect of proanthocyanidins on stamina and activity of antioxidase in mice
Objective To study the effect of proanthocyanidins（PC） on stress ability of mice and contents of superoxide dismutase（SOD）and malondiadehyde（MDA）in blood,and to further investigate anti-aging mechanism of action of PC.Methods Mice were divided into three groups at random： large dose group,small dose group and control group.The experiments of fatigue-resistance in swim and hypoxia-resistance in normal pressure were performed on mice.The contents of MDA and SOD in blood in PC group were determined and compared with those of control group.Results PC extended the time of actively swimming and enhanced fatigue-resistance ability of mice;PC extended hypoxia-resistance time in normal pressure and raised hypoxia-resistance ability of mice;PC obviously increased the content of SOD and reduced the content of MDA comparing with those of control group,and the differences were considered statistically significant（P0.01）.Conclusion The antioxidation of PC is satisfactory in vivo and it can delay aging.
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