Changes in anti-oxidation activity and renal function in mice with subacute fluorine poisoning
Objective To explore the changes of anti-oxidation activity and renal function in mice with subacute fluorine poisoning.Methods The experiment lasted for 10 days.Forty Kunming mice were randomly divided into control group（n=10）and poisoning group（n=30）.Each group included equal numbers of male and female mice.Mice in control group were intraperitoneally injected with normal saline（13 ml/kg per day）,and mice in poisoning group were intraperitoneally injected with sodium fluoride solution（1.0 g/L,13 mg/kg per day）.The tail blood of mice were collected on day 10 and the blood glutathione peroxidase activity（GSH-Px）,concentrations of malondialdehyde（MDA）,urea and creatinine（Cr） were determined.Results The MDA concentration was significantly higher in poisoning group[（7.39±1.67）μmol/L]compared with that in control group[（5.89±0.81）μmol/L]（P0.01）.No significant differences were observed in GSH-Px activity and concentrations of Urea and Cr between the two groups.Conclusion Subacute fluorine poisoning has negative impact on the anti-oxidation activity and no impact on renal function in mice.
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